Blameless Macbeth Essay

Macbeth, a tragic play by William Shakespeare, involves the downfall of a military hero, Macbeth. Our hero, however, is not to blame for his own fate à ¯Ã‚ ¿Ã‚ ½ the downfall of Macbeth is the result of the actions by those around him. Three evil withes foretell that Macbeth will become Thane of DCawdor and even King of Scotland. Macbeth dismissed their prophecies, but after he is promoted to Thane of Cawdor for military action, Macbeth wonders if he shall not be King, too. Macbeth is a good and loyal kinsman who would never harm his King. Were it not for outside forces, he would have lived happily as Thane of Cawdor, an illustrious title in itself. Macbeth does not even want to kill King Duncan. He says à ¯Ã‚ ¿Ã‚ ½chance may crown me without my stir.à ¯Ã‚ ¿Ã‚ ½ Fearing the withes message means that he will kill the king in the future, he says à ¯Ã‚ ¿Ã‚ ½Present fears are less than horrible imaginings.à ¯Ã‚ ¿Ã‚ ½ Macbeth writes to his wife, telling her about the withes and how one prophecy has already come true. As soon as she hears about it, she calls on evil spirits to fill her full of cruelty so that she will the King if necessary. Macbeth, one the other hand, does not like a possible future by the withes prophecy: that he will kill his King. This shows the difference between Lord and Lady Macbeth. It is only after much nagging and cajoling from his wife that he decides to go through with it, and then halfheartedly. His wife uses insults, demeans him, and makes him feel less than a man, so Macbeth finally gives in. While Lady Macbeth is the one who sets the ball rolling, to use an analogy, it was the witches that put the ball at the top of the hill,. The three withes are a physical manifestation of evil. They conspire to kill as many mortals as possible, under their à ¯Ã‚ ¿Ã‚ ½superior,à ¯Ã‚ ¿Ã‚ ½ Hecate. Using their evil ability to see into the future, they can tell that by using Macbeth as a tool for destruction, the maximum destructiveness will be reached. To get Macbeth to do their evil biddings, the first influence this seed of evil into his mind. By giving Macbeth that prophecy, they ensure that their plans will work.The prophecy is a self fulfilling one: for the future to be as it turns out to be, someone must know of it. That person is Macbeth./ The withes plan probably would not have worked if they hadnà ¯Ã‚ ¿Ã‚ ½t counted on the ruthless ambition of Lady Macbeth. After he meets the witches, Macbeth thinks out the idea of killing Duncan calmly and rationally, then eventually decides not to do the deed. This is both morally good as well as sensible: an usurper would not be able to hold an unsteady throne for long. Some of the evil of the play Macbeth, however, is attributable only to himself and can be blamed on no-one else. The murders of Banquo and Macduffà ¯Ã‚ ¿Ã‚ ½s family are his fault alone: his paranoid tendencies alone are the reasons for the murder. Macbethà ¯Ã‚ ¿Ã‚ ½s murder of Banquo is due basically to the fact that Macbeth does not want all of his work to go to Banquo, and he is paid back for this by being tormented by his ghost. Macbeth kills Macduff and his family: some of which is unnecessary evil alone. The witches tell Macbeth to fear Macduff, his true enemy, but the murder of his whole family is a pointless monstrosity. Macbeth is ion the precipice of instability, and the murder of the family of Macduff is the start of after he has fallen in. Macbeth tends to get rash and indecisive as the play goes on. First he is swayed by Lady Macbeth, and then he seems to act very illogically. This is another facet of his paranoia. Macbeth wants to stay king, so he hires murderers to slay all who oppose him. In the last act he becomes crueler and crueler, lashing out with feverish intensity at all those around him, even those trying to help him and innocent bystanders. That last statement is not just metaphysical, though: Macbeth is diseased of both the mind and sol. In conclusion, Macbeth is both a victim of external forces and some of his fate. The withes and his wife are both evil influences on him in the first part of the play. In the last acts, however, he is in control, but he exercises this power badly. Like most tragedies, Macbeth, the main character, has a fatal flaw in his character. Macbethà ¯Ã‚ ¿Ã‚ ½s hamartia is the fact that he is too sharing in his ambition. He opens up his path in life to include others as well, namely the withes and his wife. After that event, the true Macbeth is gone, another traveler on the road of evil. This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/ This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/ This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/ This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/ This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/ This document was downloaded from Coursework.Info – The UK’s Coursework Database – http://www.coursework.info/

Succubus Shadows Chapter 5

I stared at him, and the world stood still for a moment. â€Å"Wait†¦Seth was meeting Simone there?† Roman shook his head. â€Å"I wouldn't say that exactly. It was more like she sought him out. He looked like he'd been working there for a while when she showed up.† â€Å"And then?† My voice was very small. â€Å"Then, she walked over to him and shyly introduced herself as a fan, saying she recognized him from his website. Picture perfect demure coquette.† â€Å"And then?† â€Å"She said she wished she had a book with her to sign and asked if he'd sign a piece of paper instead. He said he would, and then she sat down, all apologetic for bothering him. She said she had a couple questions and hoped he wouldn't mind if she stayed for a few moments.† I noticed then that I was clenching my fists. With a deep breath, I released them. â€Å"Seth wouldn't strike up a conversation with a stranger like that. Not without being horribly uncomfortable.† â€Å"Yeah,† Roman agreed. â€Å"He definitely had some of that social awkwardness.† There was a wry note in Roman's voice that I didn't like. The two men had once been rivals for my affection, and apparently, Roman was still holding on to some bitterness – and a feeling of superiority. Roman could be quite charismatic when he wanted. â€Å"But she did a pretty good job at playing just as shy and nervous. I think it made him feel better.† â€Å"So she did sit down?† â€Å"Yup†¦and stayed for about a half-hour.† â€Å"What?† I exclaimed. My volume made Godiva jerk her head up from a nap. â€Å"Did she try to seduce him?† Roman's expression turned considering. â€Å"Not in the usual way. I mean, she wasn't as boring as usual. But she put him at ease enough that he relaxed and seemed to like talking to her. She wasn't overtly sexual, and he didn't look like he wanted to jump her. It was just†¦I don't know. A nice conversation. Although, it had a few of those annoying facts she likes to drop.† He paused. â€Å"Oh, and she went brunette.† That bothered me more than it probably should have. â€Å"But he sent her away, right?† â€Å"No, Maddie showed up, and he left with her – after telling Simone it was nice to meet her.† Oh, irony. Never, never would I have imagined I'd be so relieved to have Maddie show up and take Seth home. I also never thought I'd be glad his devotion to her would keep him from falling prey to another woman's charms. I took a step toward Roman, my fists clenching again. I didn't blame him as messenger; I was simply driven by my own fury. â€Å"What the hell?† I demanded. â€Å"What fucking game is she playing?† He sighed. â€Å"I don't know. Maybe no game at all. She likes coffee. I've certainly seen her buy it before. She could have ended up there by coincidence and thought he looked like a good catch. God only knows why.† I ignored the barb. â€Å"Oh, come on, Roman. You're not that stupid. Do you honestly think that in a city like Seattle, out of all the men here, it's a coincidence that she shows up and starts hitting on my ex? You know as well as I do that there aren't many coincidences in our world.† â€Å"True,† he admitted, setting the remnants of his dinner on the coffee table. The cats went for it. â€Å"Will you stop doing that?† I demanded. â€Å"They're not supposed to be eating that kind of stuff.† â€Å"Don't take your bitchy attitude out on me.† But he stood up and took the plate to the kitchen. When he returned, he crossed his arms over his chest and stood in front of me. â€Å"Look, you're right to a certain extent about coincidences. It is weird that she would hit on Seth. But think about this too: don't you think there are a few things around here a little more important than your ex-boyfriend? Jerome's theory makes the most sense, you know. Hell let him keep his job, but that doesn't mean they're letting the whole incident go. They're the ultimate grudge-holders. They'd want to assess the situation. That's why she's here.† â€Å"Except that she's not assessing anything! Unless you consider my friends' Pictionary skills.† â€Å"You should have seen them play Jenga.† â€Å"This isn't a joke. I need to figure out what her game is. You have to take me with you when you spy on her again.† He raised an eyebrow. â€Å"I think that's a terrible idea.† â€Å"I can go invisible.† â€Å"She'll still sense you.† â€Å"You can hide my signature. You told me before that you could. Was that a lie?† Roman grimaced. Just before things had literally blown up between us, he'd asked me to run away with him, promising he could conceal me from the greater immortals. â€Å"I can,† he admitted. â€Å"But I just think you're asking for trouble.† â€Å"What am I risking?† â€Å"A lot. Whether it's Seth or Jerome, there's obviously something going on. Get tangled up in that, and you could be risking your life. I won't let that happen to you.† â€Å"Since when do you care what happens to me?† I asked incredulously. â€Å"Since you became my ticket to rent-free living.† And with that, he turned invisible, hiding his signature as well. â€Å"Coward!† I cried. My only answer was the front door opening and then shutting. He was lost to me, and I realized I'd again missed my chance to bring up my weird encounters from these last couple days. I tossed and turned again that night, but it had nothing to do with my fear of walking off the balcony or into Puget Sound. I was filled with rage, both at Simone for making the moves on Seth and at Roman for abandoning me. When I woke up in the morning, I took comfort in knowing I didn't need Roman to confront Simone. I could do that on my own. Of course, there were a few complications there, the first being I didn't know where Simone was. Her hotel was probably the logical place to start, though most succubi – even a bland one like her – wouldn't spend a lot of time hanging out there. Well, unless she had company – and I didn't really want to walk into anything like that. And anyway, I had one tiny commitment to attend to before I could go bitch-hunting. Maddie. I'd regretted my decision to go shopping with her the moment the words had left my mouth. Yet, somehow, I'd totally blocked out those feelings yesterday when I'd been sitting with Seth. A brief thought about the wedding had flitted through my mind†¦and then it had been gone. I'd spent the rest of the time laughing and talking with him as though there was no Maddie in the world. But as I headed over to the bookstore, where she and I had agreed to meet, I had to accept reality once more. Seth was no longer mine. He also wasn't Simone's. But I'd deal with that later. Maddie was waiting for me downstairs, but I used the excuse of needing coffee before we left, in order to dash up to the caf? ¦. I wanted to see if Simone was lurking. No matter her shape, I'd know if she was there. Yet, as I casually waited in line for my white chocolate mocha, I sensed nothing immortal. Seth was there, engrossed in his work, and never even saw me. Apparently, his muse was still going strong. I let him be and joined Maddie downstairs again. She had a list of eight store names and addresses. Most were dress shops, and I was skeptical that we could make them all before we were due into work. She was more optimistic, but then, that was typical of her. â€Å"No point in worrying right now,† she said. â€Å"We'll just do them one at a time and see where that gets us. Besides, the last few are bakeries, and we wouldn't want to eat a bunch of cake before trying on dresses.† â€Å"Speak for yourself,† I said, sliding into her passenger seat. â€Å"I'm not trying anything on.† She gave me a wry smile. â€Å"Aren't you? You're my bridesmaid, remember? We talked about it at the party.† â€Å"No,† I said swiftly. â€Å"I said and did all sorts of crazy stuff that night, but I never agreed to it. That I do remember.† Maddie's expression was still light, but I thought I heard a little hurt in her voice when she spoke next. â€Å"What's the big deal? Why don't you want to be one? You know I'd never dress you in anything horrible.† Why? I pondered the answer as she pulled into traffic. Because I'm in love with your future husband. I could hardly tell her that, of course. As it was, I could see my continuing silence was making her feel worse. She was reading it as a slight to our friendship. â€Å"I just†¦I just don't like all the, uh, fanfare that goes with weddings. There's so much planning and stressing about little details. I'd rather just sit back in the audience and watch you go down the aisle.† Well, actually, that was one of the last things I wanted to do. â€Å"Really?† Maddie frowned, but thankfully, it was more out of surprise than disappointment. â€Å"You're always so good at planning and little details. I thought you were into that.† That was a fair point. It was why I made such a good manager. â€Å"Yeah, kind of†¦but I mean, at the receptions, drunk guys always hit on the bridesmaids, you know? They think we're desperate because we're the ones not getting married.† Also not entirely far from the truth in my case. Maddie's smile returned. â€Å"Those are some pretty lame excuses.† They were indeed, but she said nothing more as we drove. After Maddie's initial failure with picking flattering wedding dresses, she now threw her faith completely into me to lead her to fashion success. It wasn't the first time this had happened, and I found myself slipping into style-advisor role pretty easily. In fact, if I was able to preoccupy myself with the objective parts of this process – flattering fit, color, etc. – it was easy to block out the big picture of her and Seth. The saleswomen working at the stores soon learned who was in charge here and backed off with their recommendations, simply fetching the dresses I indictated. I studied each one Maddie tried on, keeping my standards high. With so many stores to choose from, we could afford to be picky. â€Å"That one's good,† I said at our third store. It was corseted, narrowing her waist, and had a skirt that didn't flare. Those puffy ones always made the hips look bigger, though no one ever seemed to realize that. You had to be tall and thin to get away with that, not short and buxom like Maddie. She admired herself in the mirror, a look of pleasant surprise on her face. She was still drawn to ones that I didn't think were good choices, and this was the first of my picks that she really liked. The eager saleswoman jotted down the style number, and then Maddie started to turn around and try on the rest waiting in her dressing room. As she did, a dress on a mannequin caught her eye. â€Å"Oh, Georgina, I know what you said, but you have to try that on,† Maddie begged. I followed her gaze. The dress was slinky and sexy, floor-length violet charmeuse with straps that tied around the neck. You were wearing that color the first time we met. I averted my eyes. â€Å"Not ugly enough to be a bridesmaid dress.† â€Å"It'd look great on you. Everything looks great on you,† she added with a shake of her head. â€Å"Besides, you could wear that to other things. Parties and stuff.† It was true. It didn't scream bridesmaid. Not taffeta or bright orange. Before I could protest further, the saleswoman had already fetched one from the rack, guessing my size with that uncanny ability her kind had. So, reluctantly, I tried the dress on while Maddie went to her next option. The size wasn't perfect, but a little shape-shifting neatened it up where it needed to be. Maddie was right. It did look good on me, and when I stepped out, she took it as a done deal that I'd buy it – no, she offered to buy it – and would be in her wedding. The saleswoman, seeing an opportunity, and possibly getting back at me for my tyrannical attitude, had â€Å"helpfully† fetched two more dresses for me to try while I waited for Maddie. Maddie claimed she couldn't stand the thought of me waiting around with nothing to do, so I reluctantly took them into the dressing room. They too looked good, but not as good as the violet. I was returning them to the saleswoman when my eye caught something. It was a bridal dress. It was made of ivory duchess satin, the fabric wrapping around the waist and halter top. The skirt was draped, pulled into little tiers. I stared. It would have been a disaster on Maddie, but on me†¦ â€Å"Want to try it?† asked the saleswoman slyly. Something told me that bridesmaids covertly trying on brides' dresses wasn't a rare phenomenon around here. The desperate and mournful not-getting-married attitude in action. Before I knew it, I was back in the dressing room, wearing the ivory dress. You were wearing that color the first time we met. Seth had been wrong about that and corrected himself, but for some reason, the words came to me yet again. And the dress looked great. Really great. I wasn't overly tall but was slim enough that it didn't matter – and I filled out the top beautifully. I stared at myself in a way I hadn't with the other dresses, trying to imagine myself as a bride. There was something about brides and weddings that instinctively spoke to so many women, and I shared the impulse as well, jaded succubus or no. The grim statistics didn't matter: the divorce rates, the infidelity I'd witnessed so often†¦ Yes, there was something magical about brides, an image fixed into the collective subconscious. I could see myself with flowers in my hands and a veil on my head. There'd be well-wishers and joy, the giddy faith and hope of a beautiful life together. I'd been a bride once, so long ago. I'd had those dreams, and they'd blown away. I sighed and took the dress off, afraid I might start crying. There would be no wedding for me. No bridal hopes. Not with Seth, not with anyone. Those things were lost to me forever. There was only an eternity alone, no lifelong lovers, only those I shared a night with†¦. Unsurprisingly, I was kind of depressed for the rest of the day. Maddie bought the violet dress for me, and I was too glum to protest – which she read as acceptance of my bridesmaid fate. We made it through the rest of our dress stops but didn't get to the bakeries. By the end of it all, we had four candidates for her dress, which I regarded as good progress. My mood didn't abate at work. I holed up in my office as much as I could, seeking solitude and my own dark thoughts. When I finally made it home after that eternity-long day, I found the condo empty and was astonished at how much that hurt me. I wished with all my heart that Roman was around, and it wasn't even to talk about Simone or other immortal mysteries. I just wanted his company. I just wanted to talk to him and not be alone. He was an infuriating part of my life, but he was also turning into a fixed infuriating part of my life. With a gloomy eternity ahead, that meant something. I knew better than to wait up for him†¦but found myself doing it anyway. I lounged on the couch with Grey Goose and the cats, taking some small sweetness from those warm, furry creatures that loved me. Eternal Sunshine of the Spotless Mind was on, which didn't cheer me up any. Like the masochist I was, I watched it anyway. At least, I thought I was. Because suddenly, the loud shriek of a car horn blasted into my ears. I blinked and jerked my head around. I wasn't on the couch. There were no cats, no vodka. I sat on the railing of my balcony, precariously positioned. The horn had come from below, on the street. One car had nearly swiped another, and the near-victim had honked in his outrage. I didn't exactly remember the trip out here. I did, however, remember the force that had drawn me – largely because it was still there. The light and the music – that feeling of comfort and rightness that was so hard to articulate hovered before me, off in the air. It was like a tunnel. No, it was like an embrace, arms waiting to welcome me home. Come here, come here. Everything will be all right. You are safe. You are loved. In spite of myself, one of my legs shifted on the railing. How easy would it be to step over, to walk into that sweet comfort? Would I fall? Would I simply hit the hard sidewalk below? It wouldn't kill me if I did. But maybe I wouldn't fall. Maybe I'd step into that light, into the bliss that could block out the pain that always seemed to surround me lately†¦. â€Å"Are you out of your fucking mind?† The driver that had nearly been hit had gotten out of his car and was yelling at the other. That driver got out and returned the insults, and a loud tirade began. One of my neighbors on the floor below opened his patio and shouted for them all to shut up. The argument, that jarring noise, brought me back to myself. Once more, the siren song faded away, and for the first time, I almost felt†¦regret. Carefully, I climbed off the rail and back to the solidity of the balcony. A fall might not kill me, but good God, it would hurt. I walked back into the condo, finding everything exactly as I'd left it. Even the cats hadn't moved, though they looked up at my arrival. I sat between them, absentmindedly petting Aubrey. I was scared again, scared and eerily attracted to what had just happened – and that scared me more. Despite the vodka tonight, my last encounter had proven alcohol wasn't to blame. No connection. Yet†¦it occurred to me there had been a common link all three times. My mood. Each time, I'd been down†¦sad about my lot in life, seeking reassurance that wasn't to be found. And that's when this phenomenon would happen, offering a solution and the comfort I thought was beyond me. That was bad news for me. Because if this thing was drawn to woe and unhappiness, I had plenty of it to go around.

Adhesion molecules in T-cell receptor

Adhesion molecules or receptor play key role in many processes involving cellular immunity that included haematopoiesis, migration, activation and finally apoptosis. They are mainly surface glycoproteins and variation among them is mainly due to different pattern of glycosylation. Adhesion molecules play a central role in T cell activation by providing initial temporary attachment of TCR and Antigen bearing MHC on APC. It was clearly demonstrated by various studies where complete inhibition of cellular immunity was observed in response to Monoclonal antibody against many of these adhesion molecules.Cytotoxic CD8 T cells mediated immunity play a key role in viral infection control. It exerts it effect by close cellular interaction with viral infected target cells. Adhesion molecules play a crucial role in driving the effector T cell towards viral infected target cell as well as to establish interaction between TCR and APC. This article briefs the function and properties of some vital adhesion molecules such as LFA-1, ICAM and VLA-4. Further, research carried out to assess the role of adhesion molecules in T-cell receptor is also summarized.Thymus derived (T) lymphocytes are important regulatory and effectors cells in immune responses. The specificity of cellular immunity is mediated by T cell receptor-CD3 complex interacting with foreign antigen represented by MHC molecule (BARBARA E. , 1988). Activation of T cells leads to functioning of T Cells where it produces various cytokines and cell lyses. In general, CD4+ T cells act as helper cells by producing different effectors molecules after interacting with antigen bearing APC cells, whereas CD8+ cell directly exert it’s effect by killing the antigen bearing APC cells.Activation and generation of effectors T cells are mediated by TcR-CD3 complex but there are several other surface molecules that play a significant role in immune response and T cell adhesion to APC. Similarly, they have significant role in cell migration, homing and recirculation. Some recent reports indicate the role of these molecules in T cell activation and differentiation. Among many are LFA-1, CD2, CD4, and CD8. Each of these molecules interact with it ligands for example LFA-1 binds to ICAM-1 while LFA-3 bind to CD2 etc. (BARBARA E. , 1988) LFA-1:The LFA-1 molecule is member of a family of three related proteins found on lymphoid and myeloid cells having common Beta subunits of MW 95000. They are non covalently associated with a unique alpha subunit. Two other members of LFA-1 families are CR3 and p150. LFA-1 molecules are widely distributed on all thymocytes, T cells, B cells, and natural killer cells. Identification of LFA-1 was done when monoclonal antibodies against it was used to inhibit cytotoxic T cell mediated killing and later on it was found to be key molecules which helps in TCR-APC interaction as adhesion molecules.Similar observation are made where anti LFA- 1 monoclonal antibody inhibits spontaneo us aggregation or homotypic adhesions between EB virus mediated activated T cells. This clearly indicates the role of LFA-1 in strengthening the intersection. Any abnormality in expression of these groups of adhesion molecules leads to recurrent bacterial and viral infection and abolished Cytotoxic T cell mediated immunity. (BARBARA E. , 1988) ICAM (Intra cellular Adhesion Molecules): Intercellular Adhesion Molecule-1 (ICAM-1, CD54) is a transmembrane glycoprotein molecule of the immunoglobulin super family.Each of the molecules is made up of 5 distinct domains and coded by gene present on chromosome 19. It is 80-114 KDa protein having 505 amino acid residues. ICAM associated with receptor of integrin family and having key role in cell signaling and adhesion. A CD8 T cell utilizes temporary interaction between ICAM-1 and LFA-1 to initiate binding of TcR and antigen MHC. This temporary interaction or binding provides sufficient time to T cell to recognize Antigen and respond against it by activation. (BARBARA E. , 1988)The T-cell lymphocyte migration is influenced by the interactions via the adhesion molecules, the T cell receptor and cytokines. (Hauzenberger D, 1995). The motility of the T cell lymphocytes is very much and critically dependent upon the avidity of the adhesive lymphocyte receptors for endothelial cells ligand and extracellular matrix componenets and the capability of the lymohocytes to undergo a motile response. Hauzenberger D et al. , 1995 discussed that the lymphocytes are rendered motile by adhesion to endothelial cells and ECM components.This migration, which is considered directed is mediated by beta-1-integrins and special T-cell lymphocytes that possess functional specialization using either alpha 4 beta 1 or alpha 5 beta 1 during chemotaxis and hapotaxis to ECM components. It is also reported that the T cell antigen receptor cannot itself trigger T lymphocyte migration to fibronectin, laminin or collagen type IV but works in hand with s ignals via alpha 4 beta 1. (Hauzenberger D, 1995) Adhesion molecules and Systemic viral Infection: Research Studies Virus induced changes in the adhesion molecules expression on T-cells were studied by Andersson et al., 1997. They studied how the antiviral effector cells migrate into the infectious foci. It was revealed by the FACS (Fluorescent associated Cell sorting) that when systemic lymphocytic choriomeningitis viral infection occurs in cells, various cell adhesion molecules including VLA-4, LFA-1, and ICAM-1 are up regulated on CD8+ cells. The lymph node homing receptor MEL-4 was down regulated during infection, but they observed only marginal changes in CD4+ cells. Further analyses showed that T cells with a changed adhesion molecule profile presented many other cell surface markers, thus indicating a state of cellular activation.The activation was of IL-2R, and included all virus-specific CTL effectors. The researchers concluded that the hypothesis that indicates that the up regulation of VLA-4 is important for effectors T cell homing to sites of inflammation. (Andersson EC, 1994). In Concanavalin induced Hepatitis, the TNF-? induced expression if Adhesion molecules are under the control of TNFR1. This study was performed by Worl et al. , in 2001. Hepatocellular death by activation of TNFR1 is mediated, apart from this TNF also in responsible for activation of cytokines and adhesion molecules.Also leads to massive induction of adhesion molecules, like ICAM-1, VCAM-1 and E-selecting in the liver. The study also revealed, that the absence of any of the TNFrs did not change the adhesion molecules expression in the livers of ConA treated mice which leads to the conclusion that the other endothelial cell-activating cytokines up-regulated adhesion molecules expression. This study discusses the critical role of adhesion molecules, such that the upregulaton of adhesion molecules during hepatitis not only contributes to organ injury but also represent defense m echanism. (Dominik Wolf, 2001) Rhinoviruses cause common colds.This form of common cold has over 100 serotypes, the major group share a single receptor. Lymphocyte function associated molecule 1 (LFA-1) mediates leukocyte adhesion to a wide variety of cell types by binding to intercellular adhesion molecule 1 (ICAM-1). Donald E. Staunton et al. , 1989 demonstrated identity between the receptor for the major group of rhinoviruses and ICAM-1. The studies revealed that a major group rhinovirus binds specifically to purified ICAM-1 and to ICAM-1 expressed on transfected COS cells and binding is blocked by three ICAM-1 monoclonal antibodies (MAb) that block ICAM-1-LFA-1 interaction.These studies also suggested that the ICAM-1 contact site(s) for LFA-1 and rhinoviruses is identical. Moreover, ICAM-1 MAb block the cytopathic effect in HeLa cells mediated by representative major but not minor group rhinoviruses. The researcher’s concluded that intercellular adhesion molecule 1 is ind uced by soluble mediators of inflammation, suggesting that the host immune response to rhinovirus may facilitate spread to uninfected cells. (Donald E. Stauntonb, p. 1989) Apart from ICAM1 and LFA-1, other categories of adhesion molecules functioning in T cell receptors include E-selectin and vascular cell adhesion molecule-1.These adhesion molecules mediate adult T-cell leukemia cell adhesion to endothelial cells. Ishakawa et al. , 1980 studies the adhesion properties of peripheral bold leukemic cells form 10 patients with adult T-cell leukemia to endothelial cells to derive the mechanism of leukemic cell infiltration. ATL cells did express LFA-1 but the expression of VLA-4 was variable. These results, together with the detection of E-selectin expression on the endothelium at ATL skin lesions, indicated that the E-selectin-mediated adhesion is the major pathway for the adherence of ATL cells to endothelial cells.Moreover, the ligand for E-selectin on ATL cells appears to differ fro m that on neutrophils. (T Ishikawa, 1993) Bibliography Andersson EC, C. J. (1994). Changes in cell adhesion molecule expression on T cells associated with systemic virus infection. Journal of Immunology , 1237-45. BARBARA E. , B. I. (1988). T cell adhesion molecules. FASEB , 2584-2590. Dominik Wolf, R. H. (2001). TNF–Induced Expression of Adhesion Molecules in the Liver Is Under the Control of TNFR1 Relevance for Concanavalin A-Induced Hepatitis.The Journal of Immunology , 1300-1307. Donald E. Stauntonb, a. V. (198). A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell , 849-853. Hauzenberger D, K. J. (1995). T lymphocyte migration: the influence of interactions via adhesion molecules, the T cell receptor, and cytokines. Crit Rev Immunol. , 285-316. T Ishikawa, A. I. (1993). E-selectin and vascular cell adhesion molecule-1 mediate adult T-cell leukemia cell adhesion to endothelial cells. Blood , 1590-1598.

Avon Calls on Foreign Markets Essay Example | Topics and Well Written Essays - 1000 words

Avon Calls on Foreign Markets - Essay Example The brand name has also been changed according to needs, e.g. France. The logo appears on the Avon product. It uses celebrity in order to sell its products. Avon is for women and their needs. Foreign operation Avon was formed on 1886 and has changed its marketing strategy frequently. It did so in order to maintain its growth in the market (Alanfaya, 2006, p.1). Avon depends hugely on foreign markets .The reason was that since US market is full of retailers of beauty product there is no untapped market left where Avon can capture and increase its market share. Thus Avon decided to operate on less competitive market. The domestic market of Avon depends on the US market. The market comprises of less than 5% of the world’s population. Socio and demographic changes Avon showed a declining trend in the US market in the 1990’s. The percentage of people using make up went down drastically from 92% to 88%. The decline affected the age group between 18 to 24 years of people. They are the people who would spend money on trying new products. Yet market share dropped by 4% in 1996. One of the main reasons in the decline of demographic is the changing fashion (Dortch, 1997, p.1). Candace Corlett remarked that the youths like to look more natural. The growth in the cosmetic market is projected to grow for all age groups. From the above data, it can be analyzed that the US market is now growing. But Avon being a cosmetic organization, it is mostly preferred by women of all age group. The ratio of women is at a higher rate than males. This would prove to be beneficial for Avon as it’s mainly caters to women. The age group of 15 to 65 years is also dominated by women. Therefore this change could affect Avon in a positive way and generate more sales in US (CIA, 2011). When it comes to socio economic changes, Avon has established itself as a big brand. Avon categories itself as a global brand and caters to millions of women worldwide. Out of every 5women 2 wom en uses Avon product. Thus the socioeconomic changes would affect the business of Avon. The better economic rate of the people more business it would be able to generate. Global Recession The recession of 2008 did not affect much on the operation of Avon. But however if a recession hits again, the economy would experience a fall in real GDP which would lead to less spending of income. But Avon deals in cosmetic products and this industry is growing (Eucck, 2011). Customers demand more for a quality product and Avon is a brand which satisfies their needs. Avon’s strength lies on its direct sales. It provides recession proof employment. Thus a global recession would not affect the operation of Avon. Competitive Advantage Avon competitive advantage is that it brings products to its customers through direct sales. When the china market banned direct sales, Avon sold its product through small shops and malls (Parker, 2005, p.256). Avon has come up with an advantage business model, during the period of unemployment and recession. It provides economic advantage for most women in the world. Avon gives a better customer service than other companies. It provides the best direct sales, thus it would not be easy for its competitors to overcome such a difference and overtake Avon. It has got a wider geographic coverage. Avon is present globally; it is at a position where it can expand even more, which is also not possible for any of its competitors the product line is much more attractive than its

MDCM CASE Essay Example | Topics and Well Written Essays - 1750 words

MDCM CASE - Essay Example The services that are provided by the company must also be of standard quality. The company has been suffering loss in the market in spite of all its steps and strategy designed for the customers and company’s benefit. The company shares its benefits and losses with the customers in order to form close relations with the customers. With the passage of time, the company has identified the importance of its global status. It has expanded by opening many offices, branches and acquisitions in different parts of the world. However, the company identifies its lacking procedures and slowed information collection and update due to which, it goes through transformations under the heading of Horizon 2000. The company requires a well established IT strategy in order to meet the competition in the market. This paper analyzes the issue in detail. Strategic Goals of MDCM MDCM does the business of medical devices contract manufacturing and is well reputed because of its expansion with the pa ssage of time. The company has well defined strategic goals and due to some problem with meeting the goals, the company has faced continuous losses. The strategic goals of the company are as follows (Jeffery & Norton 1-7): To facilitate the customers with their required devices within due time. To develop an online ordering and account management system that the customers will be able to use themselves. To provide an end-to-end package of medical device contract manufacturing services. To design and fabricate specialized equipment used in the assembly of manufacturing services. To form close partnership arrangements with its customers. To share rewards and risks of the business with its customers. To work with customers as close as it is possible. To reduce manufacturing costs to their lowest level. To maximize customer satisfaction by delivering quality parts and assemblies on time. To expand its business by opening new offices and manufacturing facilities close to its largest cust omers. To maintain that the acquisitions that the company makes, allow the company to spread its operational excellence while keeping the foreign companies autonomous enough to be able to better serve their local customers. Competitive Environment The firm MDCM faces a strict competition in the market because of more firms in the same business. With increasing concept of globalization, more people are active in market and provide globalized facilities to their customers due to which, all the firms face challenges to work towards success and expansion of their business on global basis. MDCM has designed a strategy to form good and close relation with its customers by involving them in their business as the company used to share its rewards and risks with its customers. However, with new businesses introduced in the market, this practice was copied and conducted by other businesses as well due to which, a competitive environment was created in the market (Jeffery & Norton 3). As a com petitive strategy, the company MDCM opened many offices at locations, which were near to their largest customers. Along with offices, the company also made a number of acquisitions. According to Jeffery & Norton (2006), â€Å"the acquisition targets were all non-US-based companies that had competencies in contract manufact

Evaluation of producer strategies (Spartan Energy Corp) Assignment

Evaluation of producer strategies (Spartan Energy Corp) - Assignment Example During 2014 second quarter, the company average production stood at 6,396 boe/d which consisted of 93% oil and liquids. The production costs reduced to $ 18.23 per boe while the administrative expenses reduced to $3.11 per boe. During the same period, the company attained $24.4 million as funds from operations. During the first six months that ended in June 30, 2014, Spartan net income stood at $16,357 million. As a company that takes into consideration the interest of the stakeholders, Spartan Energy Corp has adopted the culture of using modern technology in its production facilities. For example, through the use of 3-D seismic coverage, the company is in a position to identify areas with oil and other minerals. Additionally, the company has invested in modern drilling equipments that make it to improve its operations. Through the extensive research and innovation by the company, it is targeting to achieve 15,000 boe/d in the next 24 months. As a company that deals with oil, Spartan is exposed to various risks. For example, wet weather in southeast Saskatchewan has negatively affected drilling process in that region. As a result, the company has experienced delays in drilling. To deal with the risk of weather, the company first stops to drill in such areas until it is deemed fit to drill again. In addition, the company has established wells in more areas so as to ensure its operations are not affected once wet weather is experienced in some regions. Spartan Energy Corp is concerned with various government policies. For instance, the company provides audited financial statements to its shareholders. In addition, the company has a culture of conserving the environment during its activities. In this way, it acts in line with the government environmental conservation laws. The company adopts a whistle blowing policy that ensures that accounting frauds are detected as outlined

How Do Infrastructures Sape Cultures of Consumption Essay

How Do Infrastructures Sape Cultures of Consumption - Essay Example This essay stresses that the government of a country provides Infrastructure Services like Transport, Water & Electricity to promote well being of the citizens and hence will be committed to subsidize the cost to the consumers in order to make them reachable to the most unprivileged in the society. However, it needs to be clearly communicated that Infrastructure Services resulting in consumption of natural resources (like water) that is of utmost environmental importance should not be treated as a product which can be availed as per personal choice without any commitment to the larger community & the environment. The consumers would have to be educated on the bigger picture such that they assume larger accountabilities of preservation of the natural resources thus helping in reducing wastage. This can be done by promoting products & services that help in waste reduction without compromising on the day to day lifestyle goals of the individuals. Moreover the services are allowed to be controlled by non-profit organizations such that the cause of environment protection is higher on agenda than the revenues from services. This paper makes a conclusion that the design of end user utility services in large buildings & households should be done in such a way that manual avenues of saving natural resources (like water) should be provided along with signage or short instructions rather than controlling wastage through automatic means. Human behaviour would override the automatic systems more often thus resulting in more wastage than conservation.

Investigate a precolonial African polity in terms of its key Research Paper

Investigate a precolonial African polity in terms of its key constituent institutions - Research Paper Example Political centralization was the key component of pre-colonial institutions. Pre-colonial African polities have been in existence in the earlier years as a broad ground for the provision archeological research of the civil compatibility and the country. Much of the twentieth century, pre-colonial African countries were misunderstood because of the outward encouragement. Archaeological research is done on these states, however, shows the native origin of the social compatibilities and the countries in Africa, putting in place valuable new ideas for the provisional research in the earlier years on the formation of a state. It tries to analyze how the archaeologists have handled the state of pre-colonial in Africa, starting with listing of the colonial-era based on the state of the country and the advancement in Africa. Then followed by showing how insights into the political processes across the continent are provided by power through a discussion of archaeologist. Major illustrations are made within wide elaborated divisions; at the end of this review, (a) Driving state formation across the continent, because of the agency of indigenous political entrepreneurs. (b) How the pre-colonial African countries political contours were well shaped through having alternatives modes of power. The countries that were in place even before the colonial rule progresses to mould its recent advancement, pre-colonial countries control is attained with the recent cross country distinction in attainment of school, literacy, roads being paved, and immunization. Most of the countries in the West Africa rejected the French settlement as they had centralized form of government. Similar parts of the west Africa were among the states that received low investments in the colonial period. The pre-colonial states in Africa had all it takes to have full control of the people instead of the land. Below are the several factors that led to this: †¢ Agriculture, this demanded a

Policy Evaluation Analysis Research Paper Example | Topics and Well Written Essays - 1750 words

Policy Evaluation Analysis - Research Paper Example Currently, public education in the US is offered by district public schools and Charter schools according to Stuart (2002). Charter schools are not government-run, instead, they are opened and attended by choice. The policy of funding Charter schools using federal funds was authorized by President Bush in the NCLB Act in order to stimulate their development. However, this is done indirectly done by transferring the money allocated for each child enrolled in a Charter school, from their former district schools. This means that the relationship between a Charter school and the district sponsoring it could facilitate or hinder its access to federal funding (US Government Accountancy Office 1998). Some Charter schools are considered as LEAs and receive direct deferral funding. Finnigan et al (2004) and Ascher et al. (2004) state that in terms of funding, charter schools receive funding according to enrollment. In many cases, Charter schools receive lesser funds as compared to other publi c schools due to imperfections in money transfers (Reville, 2007). Stuart (2002) adds that Charter schools do not receive funding for securing facilities. This causes them to seek operation costs outside the federal funds for example through donation. However there is a recent federal legislation which allows that allocation of start-up costs to Charter schools. This paper gives an evaluation and analysis of this policy. Policy evaluation time The policy of using federal money to fund Charter schools has to be evaluated before the end of the next financial year. This is because the results from the evaluation will be useful in determining any changes that are required in terms of funding. For example, it will help in determining the effect of this funding policy on Charter schools since it started in 2002 as noted by Finnigan et al. (200). These include the performance of Charter schools, costs, quality, program, and goal attainment levels. A knowledge of the extent of the achieveme nt of its goals will therefore determine amount of funding or additional funding required. These changes will then be included in the next federal budget and will be reflected in the amount of money set aside for public education. Policy evaluation process According to Theodoulou and Koffins (2004), policy evaluation is a critical way of determining whether a policy works or not, whether it is achieving its intended functions and whether its impacts are intentional or not. In order to determine the successful implementation and outcomes of a certain policy, an all round evaluation has to be conducted. This means that an application of the four policy evaluation typologies should be done. These include process evaluation, impact evaluation, outcome evaluation and cost-benefit evaluation. Process evaluation analyses how well a certain program or policy is being implemented. It is normally done with an aim of determining necessary actions that are required to improve its implementation . In order to achieve this, the government has to determine why the policy is performing at current levels and identify any problems. This requires the use of sampling in order to determine the extent to which Charter schools have been receiving federal funds, the amounts and effectiveness in delivery of funds (Theodoulou and Koffins, 2004). The government has

Images of Arabs and Muslims in Western Media Research Paper

Images of Arabs and Muslims in Western Media - Research Paper Example The scope of media does not limit itself to the mere digital media, the press and other forms of paper publications are another source through which the role of representation of Muslims has been questioned at large and has resulted in resentment in the Muslims ranks (Rane, Martinkus, & Ewart, 2014,p. 129). It is an established fact that media plays a central role towards the creation of public opinion about a given phenomena. The Western media has been highly active in the regard of taking on the Muslims and Arabs with regard to their religious beliefs and responses to the Western life styles. Similarly the Western media has followed the different debates and topics extensively with regard to the modern concepts such as terrorism, concept of veil and other radical mindsets that are prevailing in the recent times on account of conflict between different political ideologies (Janson, 2011). It cannot be denied that the two societies (Muslims and West) had their share of differences with each other through the different traces of history. Yet that is not peculiar to the two societies and conflicts have emerged within West among the followers of Christianity as well. But that has never led to such a deep debate and isolation of the two mindsets from one another. It has not created such a rift and gulf between them creating serious fault lines that may lead to mutual co-existence as a virtual impossible within one living space. For example the element of Crusade, the Ottoman Empire and the Christian subjects handling, the nationalistic uprising in the Arab world towards the early part of twentieth century. Yet none of these went on to become a stigma and both the societies and people of the two belief groups moved on as soon as the issues were resolved. The case of terrorism and modern day hatred has given a relatively prolonged outlook to the

On line data sources( 330) Essay Example | Topics and Well Written Essays - 500 words

On line data sources( 330) - Essay Example In this same case, there are various reasons as to why people carry out homicide attacks. The primary reason is that there is a lacking of something or on the other hand there may be a need in something. There are quite a number of questions that an individual can ask when it comes to this issue of homicide. There is some relationship in this connection. The first reason is that when a child lacks the necessary education he may end up failing and not graduating. This brings lack of a way of fending for himself. The next option may be to resort to crime, in this case violent crime. In this particular case also there is a relationship. Poverty is the center of focus in this case. It is seen that when a person is living in a society where poverty is prevalent there is bound to be the feeling of coming up with a way of earning a living. (Williams, 2007) It may be pretty hard to find legitimate ways of doing this. What people opt for is the easy way out. This is particularly to do with crime. In the course of criminal activities the individuals may end up resorting in violent activities that may be detrimental to others and in this particular case such an act may be homicide. At the same time there are other reasons that may trigger homicide cases in the society. One of this is the urge to fit into a given group. This is an act which is particularly conducted by individuals in gangs or criminal groups. It is seen that for one to be inducted into such a group he or she has to carry out an activity say robbery or killing someone. This is where homicide comes in. As it has been seen there are various motivating factors when it comes to homicides. At the same time it should be noted that when it comes to homicides it is not just an act that is undertaken singly. In most cases it is usually tied down to some factors that are prevalent in society, education and the economic factors being chief

Comparison of the systems Essay Example for Free

Comparison of the systems Essay In this assignment you describe and compare the circulatory, skeletal, and respiratory systems of sharks, iguanas, eagles, and humans. Answer each of the following questions in 25 to 50 words. Circulatory System Shark How would you describe the structure and function of this animal’s circulatory system? Include any unique characteristics. The shark’s heart which is a major component in its circulatory system is shaped like an S and is located in the head region. The sharks hear has 2 chambers and atrium and a ventricle. Blood is pumped by the heart through the afferent brachial arteries to capillaries in the gills where the blood is oxygenated. How does this animal’s circulatory system work? The circulatory system centers around the heart where blood is pumped through arteries then through tissues of the body to distribute nutrients throughout the body and back to the heart. Iguana How would you describe the structure and function of this animal’s circulatory system? Include any unique characteristics. The Iguana has a unique situation when it comes to the circulatory system because the Iguana has a 3 chamber heart. Two of the chambers of the Iguanas heart are atria and one is ventricle. The ventricle has the job of keeping oxygenated blood from being mixed in with de-oxygenated blood. How does this animal’s circulatory system work?Since the Iguana has a 3  chambered heart it would not be uncommon for the Iguana to have a circulatory system that is double. Because the Iguana has a double circulatory system this causes blood to have to pass through the heart twice. Blood first flows from the heart of the Iguana to the lungs and then back to the heart where it is then distributed throughout the Iguanas body using tissues, after the blood leaves tissues it flows back to the heart. Eagle How would you describe the structure and function of this animal’s circulatory system? Include any unique characteristics. How does this animal’s circulatory system work? Human How would you describe the structure and function of this animal’s circulatory system? Include any unique characteristics. The human circulatory system is like a recycling system. The heart is a main part of the circulatory system. The heart pumps to help blood move throughout vessels in the body. Blood vessels which include arteries carry blood from the heart to tissues in the body to keep them alive. Veins carry blood back to the heart from the tissues and capillaries which are tiny veins that connect the arteries and veins. The primary role of blood in the circulatory system is to transport substances to and from all parts of the body How does this animal’s circulatory system work? As blood moves throughout the circulatory system it is acting as a transporter picking up and dropping off substances as it flows. Oxygen is picked up from the lungs and nutrients from the food digested is picked up from the intestines and is delivered to the heart where it is sorted and redistributed to the body getting rid of things the body doesn’t need in the process. What is similar in all of these circulatory systems? What is different in all of these circulatory systems? Respiratory System Shark How would you describe the structure and function of this animal’s respiratory system? Include any unique characteristics. Sharks can respire by pumping water over its gills. When the shark open and closes its mouth water enters into the mouth then the gill chambers. Water then exits through gill slits, while in the gills blood filiments absorbs oxygen from the incoming water. How does this animal’s respiratory system work? A sharks respiratory system has no blood vessels and receive its oxygen directly from surrounding tissues and fluids Iguana How would you describe the structure and function of this animal’s respiratory system? Include any unique characteristics. How does this animal’s respiratory system work? Eagle How would you describe the structure and function of this animal’s respiratory system? Include any unique characteristics. How does this animal’s respiratory system work? Human How would you describe the structure and function of this animal’s respiratory system? Include any unique characteristics. The respiratory  system of humans is quite complex as air enters into the human body it comes into contact with the diaphragm and other muscles of the thorax known as the chest that acts as an air pump. When the air enters the lungs which constitute as the exchange surface taking from the air what the body needs and getting rid of what it does not. After the air has entered the lungs and needed CO2 and O2 is extracted air then leaves through airways like the nose, mouth trachea and bronchi. How does this animal’s respiratory system work? The human respiratory system takes the air that enters in to the human body and extract needed oxygen from the air and distributes it throughout the body. The human respiratory system also acts as a protector from unsafe particles that may be taken in. The human respiratory system will get rid of all bad or unneeded air. What is similar in all of these respiratory systems? What is different in all of these respiratory systems? Skeletal System Shark How would you describe the structure and function of this animal’s skeletal system? Include any unique characteristics. Sharks belong to a special group of fish called Elasmobranchs which are fish with no bones. A shark’s skeleton is completely made up of cartilage. Some parts of the shark’s skeleton like the vertebrae are calcified. How does this animal’s skeletal system work? The shark’s cartilage does not contain any blood vessels so it receives its oxygen directly from surrounding tissue and fluids. If a shark does not constantly move it will sink, which is where it cartilage skeleton comes in handy giving the shark the ability to float. A complete cartilage skeleton allows the shark to be very quick and agile. Iguana How would you describe the structure and function of this animal’s skeletal system? Include any unique characteristics. How does this animal’s skeletal system work? Eagle How would you describe the structure and function of this animal’s skeletal system? Include any unique characteristics. How does this animal’s skeletal system work? Human How would you describe the structure and function of this animal’s skeletal system? Include any unique characteristics. The human skeleton is made up of mostly rigid brittle bone. The human skeleton is mostly cartilage as babies but changes to bone as humans get older. Cartilage is a firm but flexible material and it is hard but not brittle. The human skeleton needs a combination of rigidity and flexibility and must provide a strong foundation for skeletal muscles. Cartilage is in places where firmness and flexibility are needed such as connections between individual bones. How does this animal’s skeletal system work? Human skeletal system works by the use of contracting muscles. When muscles generate force by contracting or shortening to move the human skeleton the system is at work. Skeletal muscles are attached to the bones by means of tendons which are tough bands. Muscles are a pulling not a pushing force to create movement. What is similar in all of these skeletal systems? What is different in all of these skeletal systems?

Natural Product and Metabolomics

Natural Product and Metabolomics Mass Spectrometry is often become very useful comes into the final confirmation stage of a chemical structure. This is because by noting the fragmentation pattern and the total molecular mass of compound, researchers will be able to confirm the compound’s chemical formula, followed by confirming the chemical structure proposed based on previous instrumental analyses. Nowadays, Gas Chromatography and Liquid Chromatography are coupled with mass spectrometry in order for researchers to obtain the molecular mass right after the compounds are separated chromatographically. However, GC-MS are more often being used to study natural product compared to LC-MS because LC-MS doesn’t have its database constructed like GC-MS due to the extensive range of secondary metabolites and it is hardly reproducible. (Lee Yoon et al., 2013) Researchers can confirm the compound by matching the molecular mass obtained from GC-MS with the established database, while LC-MS users will have to refe r to the data provided by previous researchers on that particular field of study. There are a lot of journals regarding the studies of primary and secondary metabolites being published and a lot of researches will insert their sample for GC-MS experiment and then compared their compound’s fragmentation pattern and also molecular weight to the National Institute of Standards and Technology libraries, which will tells researchers the structure of their compounds, even if there are no exact matching, researches will at least have a rough idea on their structure. In the early 1990s, Solid-phase microextraction (SPME) was introduced to extract compounds from samples without the use of solvent; this method is later applied on samples before undergoing GC-MS process. This technique enables researchers to extract compounds from sample in a much simpler and cheaper way since it doesn’t include the use of solvent. SPME works by adsorbing compounds into its fibre coated absorbing phase from the sample, and then inserted into GC for desorption of compound into it and then separated. (Dagostino Sanz et al., 2014) This technique is so convenient that researchers can even carry it along when going into a jungle to adsorb compounds from plant of interest and bringing it back to the lab to undergo GC-MS experiment, much more convenient than plucking a big bunch of plants sample to the lab for solvent soaking. Samples can be injected into GC-MS through either split of splitless injection; split injection system will direct most of the samples out to the atmosphere and only allow approximately 1% of it to enter the column while splitless injection system allows most of the samples to enter the column. Split/splitless system are designed to give reproducible chromatographic retention times and also to keep the chromatographic requirements of column in place, to use split of splitless, it is depending on the sensitivity required. Though splitless system allows more sample to be injected in however, metabolomics researches are better be carried out with split system because metabolites are present in wide range concentrations and it allows researchers to analyze volatile compounds eluting near the solvent peak. (Cyril Jousse, 2009) Besides plant’s metabolites, GC-MS is also very useful for bio-metabolics, some of the bio-metabolics researches are for example Chrysoula Christou et al. did a research on analysis of organic acids in human urine in clinical settings in order to develop a method for organic acid profiling in human urine, this can be useful to detect metabolics or other health disorders. Their sample was being separated by gas column and undergo quadrupole mass spectrometer in the electron ionization (EI) mode and as a result chromatogram and mass spectra shown 11 organic acids separated and identified by conducting similarity search on NIST library (3). A research was carried out by Ioannis Papoutsis and the team of research. where GC-MS method was used to determine amisulpride in blood. Amisulpride is an antipsychotic drugs which is prescribed to psychiatric patients, overdosing can cause arrhythmia, bradycardia and hypotension. (4) SPME was first used by them to extract compounds from the b lood samples and then separated by using gas chromatography and finally detected by mass spectrometer, results show that GC-MS can be used to monitor amisulpride in the blood and this can be used in pharmacokinetic studies and also forensic investigation. Archeology GC-MS is also used in assisting archaeology studies; it is especially useful when comes to determining the chemical constituents of the sample. In one of the recent archaeology research, M. Mà ©nager, C. Azà ©mard and C. Vieillescazes studied the mummification balms from the mummy skulls with FTIR and GC-MS. Twelve mummified heads were collected, the balms on the heads were extracted with organic solvent and water before introduced to GC-MS. Molecular components were eluted by using helium, and injected with split system. Samples were eluted by using helium as carrier gas with the flow of 1mL.min-1 and oven temperature was set to: 50  °C for 2 min, 50–250  °C at 8  °C ·min−1, 250–350  °C at 3  °C ·min−1, and 350  °C during 20 min. 1 ÃŽ ¼L of each sample was injected with a splitting system and the injection temperature was set at 250  °C. Mass spectra were generated by electron ionization mode with electron ionization energy of 70 eV, an ionization time of 25,000 ÃŽ ¼s and a mass range of 40–650 m/z. (5) As a result, those mummification balms were found to contain mixtures such as oils, fats, beeswax, resins, proteins, polysaccharides and minerals, these compounds are confirmed again by matching mass spectra with NIST library. With the use of only FTIR without confirmation by GC-MS, researchers will only be able to know the functional group in it without confirming the compounds. Cosmetic In cosmetic industries, chemical compounds in every cosmetic must be carefully studied as it’s applied onto human’s skin and body, therefore any mistake made will cause allergy or irritation to end users. Synthetic husk has been widely applied in cosmetic industry due ti its long-lasting odor, however, it was found that two groups of synthetic musk can cause many health disorders. Many countries have also set up regulations on the amount of synthetic musk in order to protect end users, this has become another parameter in quality control of cosmetic products. In Beijing, China, Haifeng Dong and his team of researchers conducted a research on 7 synthetic musk in cream by using SPME and then GC-MS, cream is chosen as it is the most common form of cosmetic product. (6) Cosmetic creams contains moisturizing, nutritional agent and also many lipophilic compounds. Synthethic musks have low polarity and it is also one of lipophilic compounds, which cause synthethic musks can be hardly be separated out from other liphophilic compounds. Cream samples must undergo extra cleanup steps such as by matrix solid phase dispersion method (MSPD) in order minimizes the matrix effect. Since water and isopropanol was used to separate synthetic musks from lipophilic compounds, supported liquid extraction will need to be used in order absorb water and remove interferences to give better purification. Tandem MS was used in this research in order to improve the selectivity and decrease the detection limit. This research which deals with dream shows slightly different in the preparation method compared to other GC-MS research, however, overall concept is still similar.

Aztecs Essay -- essays research papers

Aztec The Aztec Indians, who are known for their domination of southern and central Mexico, ruled between the 14th and 16th centuries. Their name is derived from Azatlan, the homeland of the north. The Aztecs also call themselves Mexica and there language came from the Nahuatlan branch of the Uto-Aztecan family.   Ã‚  Ã‚  Ã‚  Ã‚  The Aztecs were formed after the Toltec civilization occurred when hundreds of civilians came towards Lake texcoco. Late families were unfortunate and were forced to go to the swamp lands. In the swamp lands there was only one piece of land to farm on and it was totally surrounded by more marshes . The Aztec families some how converted these disadvantages to a might empire known as they Aztec Empire. People say the empire was partially formed by a deeply believed legend. As the the legend went it said that Aztec people would create a empire on in a swampy place where they would see an eagle eating a snake while perched on a cactus which is growing out of a rock in the swamplands. This is what priests claimed they saw while entering the new land.   Ã‚  Ã‚  Ã‚  Ã‚  By the year 1325 Their capital city was finished. They called it Tenochtitlan. In the the capital city aqueducts (piping) were constructed, bridges were built, and chinapas were made. Chinapas were little islands formed by pilled up mud. On these chinapas Aztecs grew corn, beans, chili peppers, squash, tomatoes, and tobacco. Tenochtitlan (the capital city) was covered in giant religious statues in order to pay their respects to the gods. In the Aztec religion numerous gods controlled an Aztec’s daily life. Some of these gods include: Uitzilpochtli (the sun god), Coyolxauhqui (the moon goddess), Tlaloc (the rain god), and Quetzalcoatl (the inventor of the calendar and writing). Another part of the Aztec religion was human sacrifices. For their sacrifices the priest would lay the man or woman over a convex (rounded) stone, then he would take a sharp knife and cut the victims heart out. They did this because they believed that good gods could prevent bad gods from doing evil things and they also believed that good gods got their strength from human blood and hearts so they had sacrifices in order to keep their gods strong. For major rituals warriors were sacrificed, for the warrior this was one of the greatest hon... ...eternity. The earth was thus created through fire and death; the earth mother had fallen, the moon goddess was dead, and her brothers slaughtered.   Ã‚  Ã‚  Ã‚  Ã‚  And so is the story of the Aztec creation. They based their lifestyle on the examples set by the gods and goddesses in the story, thus they led violent lives. The Aztecs saw no wrong in torturing, maiming, and decapitating their neighbors for the gods. They were a savage people, and this savagery would be their downfall.   Ã‚  Ã‚  Ã‚  Ã‚  In 1519 Hernando Cortes` led over 500 men into Aztec territory in search of gold, what he found were the magnificent golden statues of the Aztec deities. The Aztecs believed him to be the representative for some white skinned god, and hence feared and respected him. It was not until they saw him melting their statues and shipping the blocks of gold to Spain that they acted. They attacked Hernanado and his men, and succeeded in driving them off. However, Cortes returned later with the support of local Indian tribes that hated the Aztecs for centuries of cruel treatment to defeat the mighty Aztecs and take the empire. This ended the Aztec civilization forever.

underground railroad Essay -- essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  Introduction   Ã‚  Ã‚  Ã‚  Ã‚  The Underground Railroad, the pathway to freedom which led a numerous amount of African Americans to escape beginning as early as the 1700‘s, it still remains a mystery to many as to exactly when it started and why. (Carrasco). The Underground Railroad is known by many as one of the earliest parts of the antislavery movement. Although the system was neither underground nor a railroad, it was a huge success that will never be forgotten.   Ã‚  Ã‚  Ã‚  Ã‚  I chose to research the Underground Railroad because I have heard so much about it, but my knowledge about the subject was very minimal. I found the Underground Railroad very interesting at first. The more I learned about this movement, the more interested I became.   Ã‚  Ã‚  Ã‚  Ã‚  When I chose this topic, I was interested in learning about the entire movement in general. I wanted to learn more about the locations of the slave hideouts, and who was involved. I wanted to find what led to the start of this movement, and when it started. I was successful with my research, and learned about all the things I was hoping to find. The Underground Railroad was a remarkable pathway to freedom which freed many from slave states and left behind an incredible story to show the importance of this event to history today. Body   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  First of all, the impact of the Underground Railroad has helped form America’s legacy like no other event in our nation’s former times. (Dewine par. 4). No one knows exactly when it started, but there were definitely advanced cases of help given to runaways as early as the 1700’s. (Carrasco). Slaves had more than one reason for turning to freedom. Most were scared of being parted from friends and family, but some just wanted to live a normal life. Some slaves had it so bad that they had to escape just to stay alive.   Ã‚  Ã‚  Ã‚  Ã‚  There are several different myths as to where this legendary path to freedom got its name. Some say the name probably originated from the popularity of the new railroads. (Carrasco). Other people say it was called the Underground Railroad because of the swift, secret way in which slaves escaped. (Donald par. 1).   Ã‚  Ã‚  Ã‚  Ã‚  The Underground Railroad began in the 1700’s under Quaker sup... ...pation Proclamation by Lincoln, ending all slavery in our now free country, forever. (Buckmaster 171).   Ã‚  Ã‚  Ã‚  Ã‚  Conclusion   Ã‚  Ã‚  Ã‚  Ã‚  While doing this research paper, I have learned so much more information about this movement than I ever expected to learn. Before I had researched this project, I assumed the Underground Railroad was an actual railroad. I never realized how drastic this movement was, nor the amount of courage the men and woman had to have to participate in the act. I had never realized how callous the slave owners acted toward their slaves, or how emotionally strong the slaves had to be to put up with the abuse. I was extremely fortunate while writing this paper. I found all the information I had been looking for, although it wasn’t quite what I had expected. The outcome of this event was so much worse than I had ever imagined it to be. I feel that the Underground Railroad was an incredible movement and if this act had never started, I believe that the many escapees would not have made it out alive.   Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  

Greed in Julius Caesar :: Julius Caesar Essays

Greed in Julius Caesar Greed can disrupt a family, town, or even a country. The play "Julius Caesar" was a great example of the power of greed. In the play "Julius Caesar" the driving forces were Cassius, Brutus, Marc Antony, and Octavius Caesar. Cassius was the brother in-law of Brutus and was also the creator of the group of conspirators. Cassius was also a senator of Rome. Cassius's greed for power, good reputation, and his jealousy lead to Caesars death. Cassius had the most honorable man in Rome to help in his plot to kill Caesar. Brutus was the honorable roman which Cassius took control of. Brutus loved Rome and all of the Roman people. Brutus was actually the true leader of the conspirators because he made the important decisions. Brutus had a different motivation for killing Caesar. The conspirators killed Julius Caesar because they were worried that if Caesar had succeeded in becoming king all the conspirators would lose their power. Brutus's motive for killing Julius Caes ar was his fear of Caesar destroying the city of Rome. Mark Antony was a regular Roman citizen, who was good friends with Julius Caesar. After Julius Caesar's death, Marc Antony recited a speech at Julius Caesar's funeral to all the people of Rome. The speech caused the plebeians to destroy everything in sight. It was by his speech that Marc Antony got his revenge towards Brutus and Cassius. Octavius Caesar was the nephew of Julius Caesar. When he got to Rome he and Marc Antony teamed up to fight against the forces of Brutus and Cassius. It was at Brutus and Cassius's last battle where Octavius and Marc Antony succeeded in their plan. Cassius had many motives for the killing of Julius Caesar. One of Cassius's motives was his greed for power. Cassius believed that he should have as much power as Julius Caesar. Cassius was also worried that if Julius Caesar had been king he would lose all of his power and become another regular citizen of Rome. Cassius showed his greed for power when he would always talk about how Caesar would get so much power and he was treated like he was nothing.

Environmental Hazards Essay

If someone was to ask you, â€Å"What is an open dump? † What would you say? Would you know what to tell them? An open dump is abandoned piles of household garbage, bags of yard waste, appliances, old barrels, used tires, and demolition debris can threaten the health of wildlife, the environment, and humans. They can cause such health, environmental, and safety issues as fires or explosions, the inhalation of toxic gases, injuries to children playing in or around the dumpsites (I have personal experience of cutting my foot on broken glass as a child playing in an open dump), diseases carried by flies, rodents and mosquitos, and other hazards. Open Dumps, 1996 – 2011). Early Landfill Believe it or not, landfills go way back in history. Of course, back then they were called â€Å"garbage dumps. † For instance, early American settlers used to deal with their garbage by dumping it over the back fence, burying it in their back yards, or dumping it in rivers. They also would burn their garbage. (Amsel, 2005 – 2013). We can go even further back in history with this subject. Case in point: Did you know the cause of the bubonic plague (14th century) was too much garbage in the streets? Allow me to explain. The bubonic plague, also called, the â€Å"black death,† spread through Africa, Asia, nd Europe, killing 75 million people. What these people did not know at the time was they had too much garbage in their streets. There was so much it was in piles. These piles of garbage in turn attracted rats. The rats had fleas. The fleas carried the disease. With rats carrying the disease from place to place, the lack of sanitation made it the worst epidemic in human history. (Amsel, 2005 – 2013). Many of the early landfills were made in wetlands. These wetlands were thought to be wasteland at that time. These landfills leaked into lakes and rivers and built up gases, such as methane. As garbage rots, it gives off a flammable gas, called methane. Because of this many garbage dumps would catch fire or explode! The first garbage burning plant was built in 1885 in New York on Governor’s Island. It was called an â€Å"incinerator. † There were 300 incinerators burning garbage in the U. S. by 1914. (Amsel, 2005 – 2013). Leachate – The most serious problem with landfills is groundwater contamination. As water percolates through the ground (like water does in a coffeemaker), chemicals can be released in the ground and get carried along in a process called leaching. The resulting water with the various pollutants is called leachate. As the water percolates through Municipal Solid Waste (MSW), a noxious leachate is generated that consists of residues various decomposing organic matter mixed with various metals from rusting items in the landfills. This can funnel directly into the groundwater without correct precautionary measures. (Wright, 2011). Methane – Municipal Solid Waste is about 2/3 organic material. Because of this, it is subject to natural decomposition. Buried wastes are anaerobic, meaning they decompose without oxygen. A major by-product of this process produces a combination of about 2/3 methane and 1/3 hydrogen and carbon dioxide, called biogas. This is a highly flammable mixture. This has caused homes to explode at up to 1000 feet away and has caused some deaths. Also, gases seeping up to the surface have killed vegetation by poisoning their roots. (Wright, 2011). Incomplete Decomposition – Commonly used plastics resist natural decomposition because of their molecular structure. Microbes are unable to digest them because they are polymers of petroleum-based compounds. There have been biodegradable plastic polymers developed from other sources, such as cornstarch, lactic acid, cellulose, and soybean protein, as well as petroleum. Wright, 2011). Settling – Finally, as waste compacts and decomposes, it settles. This problem was recognized from the beginning and there have been no buildings built on landfills. Settling creates shallow depressions that collect and hold water. These can also be deep holes. This can be addressed by continuous monitoring and filling to restore it to a level surface. (Wright, 2011). Modern Landfill Modern landfills are designed to address the previous mentioned issues. The EPA (Environmental Protection Agency) has upgraded requirements for landfill siting. New landfills are to be sited well above the water table on high ground. The floor is contoured so water drains into a tile leachate collection system. The sides and floor are covered with a plastic liner and at least two feet of compacted soil. This allows any percolating leachate to drain into the leachate collection system and be treated as necessary. Layers of refuse are positioned so the fill is built up in the shape of a pyramid. It is then with at least 18 inches of earthen material and then seeded. This cap and the pyramid shape help the landfill in shedding water. The entire landfill site is surrounded by groundwater monitoring wells and periodically checked. This checking must go on indefinitely. (Wright, 2011). Mariannhill Landfill, South Africa I chose the Mariannhill Landfill, South Africa for innovative practices in making it more productive and reducing its environmental impact. In reading the description of this landfill, it seemed more like a recreation area and less like a landfill. I could tell a lot of thought and planning went into this. This landfill contains several â€Å"cells† to hold waste. Soil from the landfill area is removed and put in storage. The resulting hole is the cell. Once the cell is full the soil is replaced. Vegetation is also removed and placed in a large holding nursery on the site. This is called Plant Rescue Unit or PRUNIT. There is a barrier system in each cell to prevent harmful waste by-products from seeping into the environment. Leachate is treated on site. This is done by a biological primary treatment with sludge followed by a â€Å"polishing treatment† by a reed bed. The Mariannhill site treats landfill water to reduce leachate until the water is reusable. Mariannhill has also set up a landfill gas extraction scheme. It has been operational for four years as of 2008. It also has a bird hide and conservation area with nature trails that link up with existing green space in the metro. (Mariannhill Landfill Conservancy, 2008). This has been a truly eye-opening assignment. Little did I realize as a child that some of the areas I was playing in were so dangerous. I’m not sure if my parents knew, but they always told me to stay away from places like that. I am so thankful these places (older landfills and â€Å"dumps†) are practically figments of the imagination now. We need to take better care of our planet! Let’s all chip in!

Classroom Management Plan Essay

A human bodyroom guidance plan is the road represent for an effective t severallying and larn environment. Classrooms atomic number 18 commwholeies that wholly succeed when citizens exercise together, and embrace responsibility for their actions. It includes the physical environment, r breakines, schooltime babe-t apieceer interactions, volunteers, expectations, rules, responsibilities, and consequences. Student-teacher interaction teachers livelihood scholarly persons in schoolman and social getledge by s screeninging calm and self-consistent in all circumstances. This includes pedagogy how to divvy up responsibility for manner, making good choices, and knowledge from mistakes.Students argon more motivated when coarse respect exists (Jones & Jones, 2010). It is important for teachers to leaven recreate in savants. When students believe their teacher c atomic number 18s well-nigh them, they respect him or her. Behavioral expectations pull in expectation s argon important for student mind and succeeder. Discussion of evaluate behaviors and consequences assist in clarifying appropriate behaviors. Modeling, practicing, and role-playing teach students congruous behaviors. Negative behaviors are treated as teachable moments to continually educate students. bonus program Students who showing exemplary behavior receive level money toward the class store. Money is only given to students who scale expected behaviors or exploits. Once a month, they lead an opportunity to shop at the school store. Desk arrangement It is important for students to know each separate, and to know ab bulge each some others experiences, values, and perceptions. Desks arranged in groups promote student to student relationships and collaboration among students. Desks are rearranged end-to-end the year. instructors desk and other diddle disciplines Close law of proximity to students enhances student-teacher relationships, so the teachers desk pas s on be as close as possible with a clear liberty chit to students desks. Other work areas such(prenominal) as computer desks and practice club table are soft accessible for smooth tran vexions. smother hangings Wall hangings include school and schoolroom rules, expectations, and procedures. iodin wall includes a word-wall students build and evoke to throughout the year. Other hangings include registers, unit information, inspirational pictures, and general information. Routines and procedures Routines and procedures are established, and full from the origin day of school. They include arrival procedures, att supplantance, tiffin count, bathroom breaks, transitions within the classroom, and transitions after-school(prenominal) the classroom, passing out materials, submitting assignments, and end-of-day procedures. refer volunteers Parent volunteers are an important part of the classroom. Students hold up sex secureing their parents in the class, and around th e school. When parents volunteer, students stick out and perform better.It brooks opportunities for parents to commiserate the classroom partnership. When parents under pedestal the classroom anxiety, they can assist teachers in supporting it. Rules and Consequences To pr example disruptions, and maintain congruity in a classroom, rules and consequences must be clear and consistent. Some behaviors warrant only saying a students name, or straitsing over to the student. This provides acute re-direction without embarrassment. Other behaviors require stronger intervention, such as removal from the classroom, teacher-student-parent proveions, or business referrals.Students are capable of demonstrating mutual respect of sprightlinessings and belongings, rhytidectomy hands to be holloed upon, honesty, clean enclosuress, paying attention, and weighty work. Classroom rules support these capabilities, and are utilise to promote positive behavior and student success. The first d ay of school, students and teacher together compile a list of rules and jibe consequences. They whitethorn include side by side(p) directions, beingness prepared, respecting personal space, mutual respect for quite a little and becomingty, work piano, kindness, good manners, and safety. A rationalise outlining class rules is provided to students.Students are required to revaluation the contract with their parents and both must order of battle under nucleotideing by signing it. Consequences are designed to support rules and expectations. Behaviors whitethorn resultant role in positive or prejudicious consequences. Positive consequences reinforce positive behaviors. They may include good clubs, verbal praise, pen praise, self-pride, tiffin with the teacher, plain computer time, and give up time. Negative behaviors disrupt training and have-to doe with the classroom community. Consequences are designed to quiet disruptions, and teach students to contri scarcelye p ositively to the classroom community.Although consequences depend on behaviors, some cast out consequences may include redressing seating arrangement, lacking recess to complete assignments, cleaning up messy work areas or the luncheon room, bad tick offs, removal of fun activities, office referrals, and parent resound calls. T exact analytic thinking of Procedures Attending Assemblies An host is schedule for 1000am in the gym. Below is a parturiency analysis of going to the collection, and going okay to the classroom after the assembly. 1. The tether announces by grade order, lowest to highest, to go to the assembly in the gym. 2.teacher asks students to clear their desks, stand up, and push in their chairs. 3. Students clear their desks, stand up and push in their chairs. 4. instructor asks students to restfully line up in alphabetical order. 5. Students lightly line up in alphabetical order. 6. Teacher recaps proper assembly behavior. a. Students should sit still , keeping hands, arm and legs to themselves. b. Students should non talk during the assembly. c. If asked for volunteers, students should raise hands, not call out. d. Students should clap when the assembly is over. It is a way of saying thank you. e.When assembly ends, students remain seated until teacher tells them to stand. f.Teacher cues students to sit at their desks when they return from the assembly. 7. Teacher leads students down the residence hall to the gym. a. Stay on the right side of the hallway. b. If a trim down grade class fatalitys to pass, the students chip and wait quietly a codst the right wall while the other class passes. c. If class is passing another class, they should passing play quietly on the go forth side of the hallway. 8. infix the gym through the southeast door. 9. fade the line of students to their correct places. 10. Ask them to quietly sit down.11. Take your seat in the folding chair at the end of your class row. 12. When assembly is ove r classes bequeath exit the gym in grade order, lowest to highest. 13. Teacher stands up and reminds students to remain seated. 14. When it is time, teacher asks students to quietly stand up and remain in their line. 15. Teacher reminds students to sit at their desks when they return to the classroom. 16. Teacher reminds students to toss quietly down the hallway, retaining in line, to their classroom. 17. Teacher leads students back to the classroom. 18. Teacher reminds students to sit at their desks. 19.When students are seated, teacher thanks students for following directions, and maintaining good behavior. Substitute innovation pleasing to the class. in that location are 20 students in the class. If you get hold of assistance revel call on Katie, capital of Mississippi, or Alexis. The following is a list of students who are pulled from class. SEM Mrs. Hills provide comply get them Tuesday 100 200 Alexis, Jackson Thursday 130 230 Alexis, Jackson, Katie, Scotty Send st udents to discipline alliance Mrs. Dixon Monday Thursday 1230 100 Joey, Hailey, Eric, Steve, Lanie Send students to Speech Mrs. Johnson Monday, Wednesday 1230 115 John, Mark daily Schedule 845 850 Retrieve students from side door. 850 905 Hang coatings, stand training to basket, lunch boxes to basket, Pledge of Allegiance, morning announcements, sit at desks, attendance 905 920 Review date, schedule, recite and vocabulary words. 920 1010 Math Lesson. chew the fat lesson planner. 1010 1015 buttocks Break 1015 1030 Recess. walk of life students to and from the back door. 1035 1125 Monday computing machine Lab laissez passer students to and from Room 20 Tuesday Music Walk students to and from Room 13 Wednesday PE Walk students to and from Stage.Thursday Library Walk students to and from Library Friday Parent Art natural process see volunteer schedule 1125 1130 trick Break 1130 1200 Lunch. Students line up in alphabetical order by last name. Walk students into the lunchroom to the cashier. 1200 1220 Recess. Students depart be sent by the lunch room monitor, but please pick out them up at the back door. 1220 115 Lesson from Anthology books. confer lesson planner. 115 135 Centers 135 200 attainment Lesson. Consult lesson planner. 200 205 prat Break 205 220 Recess. Walk students to and from the back door.220 305 Activity related to lessons. Consult lesson planner. 305 320 see time. 320 325 Clear desks and put chairs on top. pull together belongings. Walk students to front door. Continue to walk Alexis, Steve, Josie, Braden, Braxton, Eric, and Kathy to bus. General Information Class lists, lesson planner, oversight plan, and essential procedures are located in the left desk drawer. Student files are in hanging folders in the right desk drawer. Occasionally, preparements to the schedule need to be made beca utilize of assemblies. recreate communicate whatsoever adjustments during morning announcements. attention is reported on the Encore package on my computer. Login information is located on the inside page of the lesson planner. You may use a class list to chink tardy and absent. Anytime the class abjures, they should quietly line up. Do not bring them anyplace until they are quietly lined up. When paseo in hallways, they should remain quiet, walk ace file, and stay to the right. At bathroom breaks, remind students of proper behavior (posted), and to wash their hands. If students need to go to the bathroom at other times, they must raise their hands and ask permission.They may not go in pairs. Any materials take for activities, or other handouts are located in the materials area in the corner of the classroom, near the sink. Students may take AR tests on the computers during Reading Time. Remind them of the computer policies (posted near computer area). Prior to recess, and lunch, remind students to be deferent and demonstrate good behavior. If students finish assignments early , they may work on other au naturel(p) assignments. If they do not have bare assignments, they may read, or take an AR test on one of the classroom computers. There is a pencil sharpener in the materials area, with a cup of pencils next to it. If they need sharpening, a different pencil sharpener is charge each day. The students may use the weewee fountain when they take bathroom breaks, to begin with lunch and recess. Students may keep peeing bottles at their desks. Classroom computers may be used during centers and for AR tests. Teachers chargeboxes are located in the mail room in the front office. ravish check the box with my name on it at least once a day. If a child is injured, he or she should be taken to the office.You may discuss with the office staff whether or not parents/guardians need to be called. When you leave for the day, please turn the lights off and close the door. In case of emergency The class evacuates the construct through the east doors. The stud ents should calmly, but pronto line up, leave the building and walk straight up the hill. If you have an emergency in the classroom, you may call the office by pressing office loss on the phone. There is a kick up alarm lever in the hallway to the left of the classroom door. In the event of a lockdown, teacher and students sit quietly by the north wall (under the coat rack).Turn the lights off, and remain silent until the principal or vice-principal comes to the door and gives the all-clear. Please chit-chat the emergency procedures for just information. Classroom charge Rules, expectations, and procedures are posted on the wall. There is class money given to students who exhibit exceptional behavior. At the end of the month, provide an opportunity to shop in the school store. The store is located in the stand up cabinet next to the bookshelves. Disruptive students should adjust their behavior when you say their name, or walk over to them.If they do not, they may be pulled asi de to discuss reasons for their behavior and how to adjust it. If they continue to be disruptive, they may stay in at recess to hypothecate on their behavior. Please consult the management plan for further details. Please leave me documentation of disruptive behaviors, and their consequences. There is a documentation form with the management plan. implementation Plan Beginning on the first day of school rules and expectations will be practiced, reviewed, and posted. They will in any case be reviewed throughout the year as necessary.To increase student ownership, there will be a rotation of student helpers who have extra responsibilities such as passing out papers, and delivering home lunches to the lunch room. Positive and prohibit behaviors will be quickly and systematically addressed to reduce disruptions. Students who are sedulous are more likely to demonstrate positive behaviors. It is important to understand students discipline styles, interests, and experiences when des igning instruction. Instructional activities should be vary to promote positive learning experiences consequently reducing misbehaviors.Differentiated and individualized instruction may be implemented to further engage students. Parents support implementation when they foster positive teacher-parent relationships, and support the classroom rules and expectations. Parents mark off their students complete assignments, and prepare them for submission. They assist teaching students proper behaviors, and the skills needed to turn positive choices. Letter to Parents dearest Parents, I am excited to delicious your child to my class. Our classroom is a community where together we will strive for success by working together, and relying on each other.To achieve success, it is important for you, me, and your child to work together. I have high academic and behavioral expectations for my students, and with your support in and out of the classroom, I believe we will have a fun, successful school year. I encourage you to volunteer in the classroom. Students bang seeing their parents in school. It allows students extra person-to-person and small group work, which is increases their performance. Being relate is as well as an excellent way to gain information on what your child is learning and experiencing while at school.Involvement in your childs education is decisive for success. I realize my students are voluminous in many different activities, but I ask you to please make school and prep a top priority. You can do that by establishing bedtimes, homework routines, reviewing end work, providing praise and support. I also ask that you contact me if you ever have questions or concerns. In addition to scheduled conferences, I will update you via newsletters, e-mail, and phone calls. Any work that has not been completed at school will be sent home as homework.In addition, your child is expected to read a minimum of 20 minutes per day, which will be tracked on a we ekly reading log. Other homework assignments will be book reports, a science project, and a country project. In addition to academic work, your child is expected to follow the classroom rules. These rules include behaving responsibly, being kind, and staying safe. I believe consequences should be appropriate. For example, if I receive a complaint from the lunch ladies that the class lunch table was left messy, the class will assist in cleaning up.I will on a regular basis update you on your childs progress and behavior. I am in truth excited about this year. I am here for your child, so please feel free to contact me either by phone or e-mail anytime. I look forward to working with you and your child in achieving success both academically and socially. Thank you for allowing me to contribute to your childs growth and success. Thank you, Lynn James ljameslovetoread. com (555) 555-5555 Strategies for Assessing Plan Effective classroom management is resilient to student success.Classr oom management plans may need adjustment depending on grade level and classroom dynamics. Academic achievement is an indicator of student success hence it is one way to assess a classroom management plan. Parents and administrators receive copies of student grades which enables them to assess classroom management effectiveness. When administrators, visitors, modify teachers, and volunteers come to the classroom, they see student behaviors. When they see students quietly working at their desks, or in centers without disruptions or chaos, they know they are in a well-managed classroom.If they see students cheering out answers without being called upon, or students everlastingly moving about the classroom when they should be at their desks working, they know it is not a well-managed classroom. Newer teachers should consult with experienced, effective teachers to assess classroom management plans. They understand the nature of disruptions in classrooms. They also understand whether o r not students are effectively learning or simply going through the motions. see teachers provide constructive criticism for any necessary adjustments. Principals or other administrators also effectively assess classroom management plans.Teachers should consult with principals for guidance in particularized areas of classroom management. They understand when students respond positively or negatively to teachers. It is helpful for administrators to review the written classroom management plan, such as reviewing strategies addressing student behavior and remunerate or incentive programs. Their experience is valuable to a new teacher. Reference Jones, V. , & Jones, L. (2010). universal classroom management Creating communities of support and result problems (9th ed. ). Upper Saddle River, NJ Merrill.